Flexible GnRH antagonist protocol versus GnRH agonist long protocol in patients with polycystic ovary syndrome treated for IVF: a prospective randomised controlled trial (RCT)
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Flexible GnRH antagonist protocol versus GnRH agonist long protocol in patients with polycystic ovary syndrome treated for IVF: a prospective randomised controlled trial (RCT).
BACKGROUND Women with polycystic ovary syndrome (PCOS) are at risk of developing ovarian hyperstimulation syndrome (OHSS) during ovarian stimulation. Use of GnRH antagonist in the general subfertile population is associated with lower incidence of OHSS than agonists and similar probability of live birth but it is unclear if this is true for patients with PCOS. Our aim was to compare the flexibl...
متن کاملFlexible Multi-dose GnRH Antagonist versus Long GnRH Agonist Protocol in Poor Responders: A Randomized Controlled Trial
Background To compare a flexible, multi-dose GnRH antagonist protocol with a long GnRH .agonist protocol in poor respo MaterialsAndMethods A randomized clinical trial of 70 poor responder patients (35 patients in GnRH antagonist protocol and 35 patients in long GnRH agonist protocol) was performed at Royan Institute, Tehran, Iran. Both groups were given a fixed dose of human menopausal gonadotr...
متن کاملGnrh Antagonist versus GnRH Agonist Long Protocol in Overweight and Obese Women with Polycystic Ovary Syndrome Stimulated for IVF
Polycystic ovary syndrome (PCOS) is the most prevalent cause of anovulatory infertility in women in the reproductive age with a prevalence rate of about 10% [1]. PCOS is characterized by both metabolic and reproductive abnormalities. According to Rotterdam criteria (2004), the patient should be diagnosed to have PCOS when two of the following are met: chronic oligoovulation or anovulation, clin...
متن کاملart outcomes in gnrh antagonist protocol (flexible) and long gnrh agonist protocol during early follicular phase in patients with polycystic ovary syndrome: a randomized clinical trial
background: since increased lh in the early follicular phase in pcos patients especially in gnrh antagonist protocol could be associated with reduced oocyte quality and pregnancy and impared implantation. the current study was conducted to determine art outcomes in gnrh antagonist protocol (flexible) and long gnrh agonist protocol and compare them with adding gnrh antagonist in gnrh antagonist ...
متن کاملFlexible GnRH antagonist protocol vs. long GnRH agonist protocol in patients with polycystic ovary syndrome treated for IVF: comparison of clinical outcome and embryo quality.
OBJECTIVES Polycystic ovary syndrome (PCOS) is a common endocrine disorder, primarily affecting women of the reproductive age. The aim of the study was to assess the clinical efficacy and embryo quality in flexible gonadotropin-releasing hormone (GnRH) antagonist protocol in comparison to the long GnRH agonist protocol in PCOS women undergoing in vitro fertilization (IVF). MATERIAL AND METHOD...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2009
ISSN: 1460-2350,0268-1161
DOI: 10.1093/humrep/dep436